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. Author manuscript; available in PMC: 2021 Oct 1.
Published in final edited form as: Biochem Pharmacol. 2020 Jul 4;180:114137. doi: 10.1016/j.bcp.2020.114137

Fig. 4.

Fig. 4.

The effect of LY3023414 on the fluorescent drug transport mediated by ABCB1 and ABCG2. The accumulation of calcein in (A) OVCAR-8 and ABCB1-overexpressing NCI-ADR-RES cells, and in (B) pcDNA-HEK293 and ABCB1-transfected MDR19-HEK293 cells, or the accumulation of pheophorbide A (PhA) in (C) S1 and ABCG2-overexpressing S1-M1-80 cells, and in (D) pcDNA-HEK293 and ABCG2-transfected R482-HEK293 cells, were measured in the presence of DMSO (solid lines) or 40 μM of LY3023414 (shaded, solid lines) or 1 μM of tariquidar or Ko143 (dotted lines), and analyzed immediately by flow cytometry. Representative histograms of three independent experiments are shown.