Table 2.

Omnibus whole-brain voxelwise LME across all participants. Significant clusters of activation for the Estradiol x Habituation (Learning Block 1 vs Learning Block 2) x PTSD severity interaction from the linear mixed-effects analysis on imaging data during the fear learning and extinction paradigm. Cluster thresholding was implemented using AFNIs 3dClustSim, in which a voxel-level uncorrected p < .001 was used with a cluster size of k>=18 and a corrected threshold of t=3.120. Images used Orig space and RPI orientation.

Region	MNI Center-of-Mass Coordinates			Peak t	Cluster Size
	X	Y	Z
Left temporoparietal junction	−46	−59	16	7.33	176
Right supramarginal gyrus	54	−23	38	−6.05	128
Left middle insula	−39	6	6	5.88	110
Right precentral gyrus	42	5	45	−6.69	68
Right V4/inferior occipital gyrus	30	−86	−4	−6.75	59
Right precuneus	10	−67	34	−4.70	55
Left temporoparietal junction	−60	−43	10	4.96	54
Right inferior parietal lobule	50	−46	40	−5.30	49
Right precentral gyrus	21	−28	60	5.40	48
Right superior frontal gyrus	21	22	53	−5.62	46
Left posterior cingulate	0	−31	33	−4.37	34
Left supplementary motor area	−4	9	45	5.20	34
Left postcentral gyrus	−59	−11	33	−4.85	33
Left hippocampus	−26	−10	−10	5.44	31
Left V4/middle occipital gyrus	−29	−84	1	−6.23	28
Right inferior parietal lobule	42	−55	50	−5.73	28
Left V4/lingual gyrus	−26	−85	−16	−5.19	27
Left cerebellum	−7	−60	−11	5.31	26
Left frontal eye fields/middle frontal gyrus	−27	29	42	5.55	26
Right V2/cuneus	4	−90	18	4.60	25
Right cerebellum	45	−59	−32	4.26	24
Right temporal pole	43	15	−19	5.36	24
Left dorsolateral prefrontal cortex (dlPFC)	−24	46	28	4.57	24
Right cerebellum	2	−46	−49	4.42	23
Left supplementary motor area	−7	−7	62	5.75	23
Left cerebellum	−16	−75	−26	5.91	22
Right temporoparietal junction	40	−59	14	−5.19	22
Right caudate	15	14	19	−4.77	22
Left interior frontal gyrus	−49	14	21	4.38	19
Right middle frontal gyrus	33	0	61	−5.63	19
Cerebellum	11	−74	−36	4.16	18