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. Author manuscript; available in PMC: 2022 Apr 1.
Published in final edited form as: Pediatr Nephrol. 2020 Apr 29;36(4):797–807. doi: 10.1007/s00467-020-04534-2

Figure 2. Nephron number in humans with hypertension (a) and renal disease (b).

Figure 2.

Few studies provided individual data on subjects with hypertension (a) and those studies that did report had a narrow age range beginning near 40 years. From this data, there appears to be significantly fewer glomeruli in the older subjects with hypertension. Data from hypertensive subjects were included from studies conducted by Keller [4] and Lenihan [86]. In subjects with renal disease (mainly Bright’s disease with chronic glomerulonephritis and cardiac disease), there is no correlation with nephron number and age. Data from subjects with CKD were included from studies conducted by Hayman [79] and Moritz [80].