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. Author manuscript; available in PMC: 2022 Apr 1.
Published in final edited form as: Pediatr Nephrol. 2020 Apr 29;36(4):797–807. doi: 10.1007/s00467-020-04534-2
YEAR AUTHORS METHOD OF COUNTING DIAGNOSES SUBJECT NUMBER AGE (YEARS) AVERAGE GLOMERULAR NUMBER (SD) RANGE
1928 Vimtrup [77] acid maceration not reported 5 children (3), adults (2) 887,399 833,992–1,233,360
1931 Moore [78] acid maceration mostly infectious 29 1–74 794,253 427,697–1,040,671
1933 Hayman and Johnson [79] acid maceration no kidney pathology 11 19–75 1,230,000 800,000–1,530,000
kidney pathology 23 23–51 393,000 156,000–1,330,000
1934 Moritz and Hayman [80] acid maceration no kidney pathology (mercuric chloride (n=3) 14 1 hr–88 1,287,500 940,000–1,542,000
kidney pathology 21 21–85 595,000 155,000–1,154,000
1973 Dunnill and Halley [81] acid maceration 18 1 day–61 908,333 600,000–1,150,000
1977 McLachlan et al [82] acid maceration 32 20–91 1,309,280 (359,960) 580,000–2,000,000
19 male: 20–91 (mean: 60) 1,363,870 (371,840)
1 13 female: 43–89 (mean: 70) 1,229,450 (340,160)
1993 Merlet-Benichou et al [7] acid maceration 28 1,107,000 655,000–1,554,000
1992 Nyengaard and Bendtsen [3] fractionator-disector no gross kidney pathology 37 16–87 608,000 331,000–1,424,000
excluded: HTN, abnormal kidney function
1993 Hinchliffe et al [11] dissector-cavalieri 16 fetuses 903,000 740,000–1,060,000
2003 Keller et al [4] fractionator-disector no HTN 10 34–54 1,429,200 531,140–954,893
HTN 10 35–59 724,307 884,458–1,959,914
2011 Bertram et al [5] fractionator-disector 398 895,711 210,332–2,702,079
African Americans 176 898,748 210,332–2,702,079
white Americans 132 894,119 227,327–1,660,232
Aboriginal Australian 19 713,209 364,161–1,129,233
> White Australians 24 861,541 380,517–1,493,665
Senegalese 47 988,263 536,171–176,4421
2008 Zhang et al [83] fractionator-disector 15 <3 months NA 246,181–1,106,062
2014 Beeman et al [66] CFE-MRI hypertensive (n=1) 3 37–68 1,110,000 740,000–1,460,000
2003 Fulladosa et al [62] MRI and protocol biopsy stable renal transplant patients 39 38 (range: 14–76) 730,000 (330,000)
2010 Tan et al [84] whole kidney Kf kidney donors 15 <45 years 821000
19 >55 years 576000
2015 Lenihan et al [85] whole kidney Kf healthy kidney donors 19 54.8 ± 6.5 641,730 396,554–713,399
2015 Lenihan et al [86] whole kidney Kf young normotensive 24 33.5 (29–42) 797,250 (443,668)
normotensive kidney donors 17 56 (55–59.6) 561,774 (225,774)
hypertensive kidney donors 10 58 (55.75–61.5) 457,752 (176,140)
2017 Denic at al [40] CT angiogram and implantation biopsy healthy kidney donors 246 18–29 990,661
11 70–75 520,410
1638 43 +/− 11.7 873,696