Table 1.

Baseline characteristics of the study population

	CRT targeted group	Lactate targeted group
N°	21	21
Age (years)	51 [45–75]	66 [55–75]
Female	48 (10)	66 (14)
APACHE score	23 [15–30]	23 [14–34]
SOFA score	11 [8–14]	12 [9–14]
Septic Source	Abdominal: 62 (13)	Abdominal 52: (11)
	Other: 14 (3)	Other: 10 (2)
	Respiratory: 14 (3)	Respiratory: 14 (3)
	Urinary: 10 (2)	Urinary: 24 (5)
Surgical Source	57 (12)	62 (13)
Time to antibiotics (min)	60 [45–120]	60 [30–60]
Fluids Pre-randomization (ml)	1550[1000–3000]	2500 [1250–3175]
MV at inclusion	95 (21)	81 (17)
MAP (mmHg)	71 [66–77]	69 [61–78]
CVP (mmHg)	8 [5–12]	8 [6–10]
Cardiac Index (l/m/m2)	3.1 [2.2–3.5]	2.8 [1.9–3.9]
Norepinephrine dose (mcg/kg/min)	0.23 [0.14–0.54]	0.29 [0.16–0.4]
Lactate (mmol/L)	3 [2.8–5.5]	4 [3–7.6]
CRT (s)	5 [3–6.5]	5 [3–6.5]
ScvO2 (%)	69 [65–78]	70 [59–79]
Delta pCO2(v-a)	8 [4–13]	7 [5–11]
P(cv-a)CO2/Da-vO2 ratio	2 [1–2.5]	1.3 [1.1–2.8]
L/P ratio	8.1 [4–13.9]	9 [4.7–14]
StO2 (%)	78 [66–82]	78 [70–83]
PDR-ICGa (%)	18 [10–21.8]	12 [10–15.4]
MFIa	1.75 [1–2.5]	2.6 [2.5–3]

Data are presented as percentage (absolute number) or median [interquartile range]

CRT Capillary refill time, APACHE II Acute Physiology And Chronic Health Evaluation II, SOFA Sequential organ failure Assessment score, MV Mechanical ventilation, MAP Mean arterial pressure, CVP Central venous pressure, ScvO₂ central venous oxygen saturation, Delta pCO₂(v-a) Difference between central venous carbon dioxide pressure and arterial carbon dioxide pressure, P(cv-a)CO₂/Da-vO₂ ratio central venous-arterial pCO₂ gradient/ arterial-venous, O₂ content difference ratio, L/P ratio lactate-piruvate ratio, StO₂ Thenar muscle oxygen saturation, PDR-ICG Indocianine greeen plasma disappearance rate,MFI Microcirculatory flow index

^aAssessed only at Hospital Clínico UC CHRISTUS