Table 2.
Measures for treatment of obesity from birth to the age at diagnosis of leptin receptor deficiency in the two patients
| Age, year (y) month (m) | Measures for treatment of obesity | Impact on weight | |
|---|---|---|---|
| Patient 1 | Ongoing | Restrictive food intake and motivation for physical activity | None |
| 0 y 9 m | 9 days stay in a paediatric clinic with caloric restriction to 600 kcal per daya | None | |
| 3 y | 21 days stay in a specialised clinic for metabolic disorders and Prader-Willi syndromeb | None | |
| 4 y 2 m | 14 days stay in a specialised clinic for Tomatis Listening Therapyc | None | |
| 10 y 4 m | 2 years outpatient psychotherapy for mother and child | None | |
| 11 y 5 m | 6 weeks stay in a rehabilitation clinic focusing obesityd | − 10.7 kg (− 9.86%), followed by weight regain | |
| 14 y 7 m | 6 months stay in a rehabilitation clinic with obesity long-term therapye | − 15.6 kg (− 6.41%), followed by 9.3 kg weight regain within 1 month | |
| 18 y 1 m | Leaving the parental home and moving into an assisted living community | − 8 kg (+ 4.26%) | |
| 18 y 3 m | 2 years outpatient psychotherapy | None | |
| 18 y 4 m | Bariatric surgery: sleeve gastrectomyf | − 38 kg (− 20.13%), followed by weight regain (overall weight reduction, 16 kg (− 8.47%)) | |
| Patient 2 | Ongoing | Restrictive food intake and motivation for physical activity | None |
| 1 y 11 m | 15 days stay in a paediatric clinic with daily 800 kcal caloric restrictiona | None | |
| 2 y 9 m | 7 weeks stay in a paediatric clinic with daily 400 kcal caloric restrictionb | − 4 kg (− 12.05%) | |
| 3 y 10 m | 1.5 years outpatient psychotherapy | None | |
| 5 y 6 m | 1 year inpatient psychotherapyc | − 14 kg (− 29.79%), followed by slow weight regain | |
| 6 y 5 m | 3 years outpatient psychotherapy | None | |
| 9 y 5 m | 3 years growth hormone treatment due to short stature and growth hormone deficiency | + 59 kg (+ 38.8%) | |
| 12 y 7 m | 4 months stay in a rehabilitation clinic with obesity long-term therapyd | + 4 kg (+ 4.0%) | |
| 12 y 11 m | Regular advice and support from the youth welfare department, psychological care and medical weight control | None | |
| 14 y 3 m | Bariatric surgery: gastric bandinge | − 49 kg (− 33.84%) | |
| 14 y 4 m | 28 days stay in a child and adolescent psychiatry after gastric banding | − 5 kg (− 3.72%) | |
| 25 y 0 m | Removal of gastric banding due to band migrationf | + 15 kg (+ 14.8%) within 4 years |
a–fRefer to Fig. 1 and display the time points of interventions and their impact on weight