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. Author manuscript; available in PMC: 2021 Jan 1.
Published in final edited form as: Acta Physiol (Oxf). 2020 Jun 25;231(1):e13487. doi: 10.1111/apha.13487

Figure 1. Effects of Angiotensin II on Macrophage Polarization.

Figure 1.

Angiotensin (Ang) II activates AT1R to generate a pro-inflammatory M1 macrophage phenotype. Ang II enhances TLR4 signaling and promotes M1 release of ROS, cytokines, and chemokines, causing more inflammation. Conversely, activation of AT2R promotes M2 differentiation, anti-inflammatory IL10 release, and tissue repair.