Table 3.
Analysis of lesion burden and several clinical characteristics based on absence/presence of rimmed lesions on baseline quantitative susceptibility mapping (QSM).
| Characteristic | Presence of Rims on QSM | ||
|---|---|---|---|
| No Rims (n = 21) | Rims (n = 18) | p | |
| On MS treatment (%) | 66.7 | 72.2 | 0.708 |
| Male sex (%) | 19.0 | 61.1 | 0.007 |
| Relapsing-Remitting (%) | 1.9 | 77.8 | 0.284 |
| Mean number of lesions on FLAIR (SD) | 25.71 (20.37) | 41.06 (29.00) | 0.061 |
| Mean number of lesions visible on QSM (SD) | 15.24 (12.39) | 29.22 (23.87) | 0.025 |
| Mean % of total lesions that are visible on QSM (SD) | 58.71 (15.92) | 72.11 (14.82) | 0.010 |
| Mean age (SD) | 48.86 (10.55) | 43.78 (11.41) | 0.157 |
| Mean symptom duration in years (SD) | 13.42 (9.58) | 11.07 (7.38) | 0.404 |
| Baseline Mean MFIS Score (SD) | 44.38 (23.34) | 37.06 (19.16) | 0.305 |
| Mean change in MFIS between years 1 and 2 (SD) | −7.47 (12.19) | −4.08 (14.12) | 0.486 |
| Mean change in MFIS between years 1 and 3 (SD) | −2.86 (10.60) | −8.45 (16.72) | 0.318 |
| Baseline Mean SDMT Score (SD) | 53.05 (12.54) | 50.56 (12.25) | 0.536 |
| Mean change in SDMT between years 1 and 2 (SD) | 4.12 (15.62) | 1.38 (7.49) | 0.566 |
| Mean change in SDMT between years 1 and 3 (SD) | 4.57 (13.26) | 2.18 (6.43) | 0.590 |
| Baseline mean T25FW, average of 2 trials (SD) | 6.14 (2.52) | 7.22 (6.53) | 0.488 |
| Mean change in T25FW between years 1 and 2 (SD) | 0.00 (1.12) | 3.62 (11.35) | 0.200 |
| Mean change in T25FW between years 1 and 3 (SD) | 0.50 (1.61) | 3.18 (13.67) | 0.472 |
| Baseline 9HPT dominant, average of 2 trials (SD) | 23.29 (8.02) | 73.78 (177.12) | 0.199 |
| Baseline 9HPT non-dominant, average of 2 trials (SD) | 29.70 (22.33) | 30.17 (14.45) | 0.940 |
| Baseline 9HPT average of dominant/non-dominant (SD) | 26.43 (13.58) | 52.11 (89.64) | 0.202 |
| Mean change in average of dominant/non-dominant 9HPT between years 1 and 2 (SD) | −1.53 (2.76) | −5.31 (10.86) | 0.177 |
| Mean change in average of dominant/non-dominant 9HPT between years 1 and 3 (SD) | 22.4 (89.5) | −5.1 (10.0) | 0.324 |
| Baseline Mean PASAT (SD) | 42.1 (14.5) | 45.0 (10.5) | 0.501 |
| Mean change in PASAT between years 1 and 2 (SD) | 5.1 (11.6) | −4.0 (8.2)* | 0.023 |
| Mean change in PASAT between years 1 and 3 (SD) | 0.6 (10.2) | −2.3 (9.9) | 0.480 |
| Baseline Mean EDSS Score (SD) | 3.6 (1.6) | 3.6 (1.9) | 0.910 |
| Mean change in EDSS between years 1 and 2 (SD) | −0.2 (1.0) | −0.1 (0.8) | 0.770 |
| Mean change in EDSS between years 1 and 3 (SD) | −0.1 (1.0) | 0.2 (0.9) | 0.389 |
9HPT = 9-hole Peg Test; EDSS = Expanded Disability Status Scale; FLAIR = Fluid Attenuated Inversion Recovery; MFIS = Modified Fatigue Impact Scale; PASAT = Paced Auditory Serial Addition Test; QSM = Quantitative Susceptibility Mapping; SD = Standard Deviation; T25FW = Timed 25-foot walk