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. 2020 Nov 2;10:18601. doi: 10.1038/s41598-020-75576-7

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Quantification of the capillary density. A HFD Apoe−/− mice exhibit microaneurysm and capillary non-perfusion zone in peripheral retina. B Microvessel density was assessed in the central and peripheral retina. C No statistically significant differences among four groups was observed comparing the central concerning vessels density, number of junctions and Mean E Lacunaroty. However, comparing the same values in the peripheral retina we observed significant differences among four groups. Data were shown as mean ± SEM. (n = 8). *P < 0.05.