Table 2.

Multivariate analysis: Pain and toxicities experiences by donors after bone marrow harvest

	N	OR	OR Lower CI	OR Upper CI	P-value
Highest toxicity level of key symptoms grade 2 to 4, 2 days after BM harvest
Autologous blood transfusion
No	2813	1			0.2708
Yes	4209	0.8663	0.671	1.1184	0.2708
Donor Sex
Female	2670	1			< 0.0001
Male	4352	0.4441	0.3857	0.5114	< 0.0001
Collection volume per donor blood volume as a % (Nadler’s)
<= 15	1706	1			< 0.0001
15 - 22	1782	1.3637	1.1682	1.5919	< 0.0001
22 - 27	1581	1.6021	1.2417	2.0671	0.0003
27 <	1883	1.8289	1.4685	2.2777	< 0.0001
Missing	70	1.5262	0.8675	2.6848	0.1424
Duration of anesthesia in minutes
<= 74	1142	1			< 0.0001
74 - 91	1178	1.0999	0.8626	1.4024	0.4426
91 - 115	1113	1.347	1.0579	1.7152	0.0157
115 <	1099	1.901	1.4821	2.4384	< 0.0001
Missing	2490	1.389	1.0596	1.8209	0.0173
Bone pain grade 2 to 4, 2 days after BM harvest
Autologous blood transfusion
No	2813	1			0.596
Yes	4211	1.1522	0.9943	1.3352	0.596
Donor sex
Female	2671	1			<0.0001
Male	4353	0.645	0.5798	0.7176	<0.0001
Duration of collection in minutes
≤36	1171	1			<0.0001
36-50	1132	1.4904	1.2848	1.729	<0.0001
50-70	1162	1.8447	1.515	2.2461	<0.0001
>70	1108	2.4433	1.8881	3.1618	<0.0001
Missing	2451	1.5126	1.2163	1.8811	0.0002
Number of marrow harvests/year at collection centers
≤ 7	1643	1			0.0011
7-15	1677	0.8562	0.6882	1.0654	0.1639
15-45	1510	0.6363	0.4842	0.8363	0.0012
> 45	1575	0.753	0.6415	0.8840	0.0005
Missing	619	0.9402	0.7082	1.2482	0.6697
Bone pain grade 2 to 4, 1 month after BM harvest
Autologous blood transfusion
No	2590	1			0.459
Yes	3953	1.1733	0.7686	1.7911	0.459
Bone pain grade 2 to 4, 6 months after BM harvest
Autologous blood transfusion
No	2402	1			0.4574
Yes	3681	0.8415	0.5338	1.338	0.4574
Donor age at bone marrow collection
18 to 29	2838	1			<0.0001
30 to 39	1730	1.3264	0.8901	1.9765	0.1652
40 to 49	1130	2.5104	1.7105	3.6844	<0.0001
50+	385	2.3874	1.2908	4.4157	0.0055