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PACAP receptor second messenger signaling in pituitary cells. The schema describes a paracrine/autocrine feed-forward mechanism to maintain a high level of PACAP in the fetal pituitary. PACAP and PAC1-R in gonadotrophs and folliculostellate cells likely contribute to the autocrine/paracrine system. The mouse PACAP promoter is depicted with three AP1 sites (−948, −448, −275) and two CRE sites (−205, −179).
