Table 4.

Simultaneous analysis of NES and endogenous steroid hormones in samples collected from women using a NES- and E2-releasing CVR (n=5).

Parameter	NES	E2	P4	E1
Assay Range (ng/mL)	0.010 – 10	0.010 – 10	0.010 – 10	0.010 – 10
Sample Concentration Range (median) (ng/mL)	0.014 – 1.471 (0.178)	0.010 – 0.312 (0.034)	0.010 – 5.791 (0.049)	0.010 – 0.416 (0.033)
Number of Sampes Quantified	550/615*	595/615	596/615	609/615
Number of Samples <LLOQ and >MDL	0/615**	17/615	18/615	6/615
Number of Samples <MDL	0/615**	3/615	1/615	0/615

^*the 65 baseline samples for each subject before administration of NES were not detected (<MDL).

^**does not include baseline samples

NES, Nestorone®; E2, estradiol; P4, progesterone; E1, estrone; LLOQ, lower limit of quantification; MDL, method detection limit.