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(A) Dose dependent confocal images of HeLa cells after 24 hours of incubation with PNA8 encapsulated in PLGA NPs and only PNA8. DAPI was used for nuclear staining. Please note the concentration of only PNA8 is provided based on loading of PNAs in PLGA nanoparticles. Red: PNA oligomers (TAMRA), Blue: DAPI (Nucleus). The scale bar is 10 μm. (B) Histogram analysis of dose dependent cellular uptake of PLGA NPs containing PNA8 in HeLa cells.
