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. 2020 Nov 2;10:18848. doi: 10.1038/s41598-020-75881-1

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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The frequency of MDSCs is increased in patients with HCC, CRLM and NET. (A) Representative gating strategy for the analysis of immune cell populations from peripheral blood. The frequency of (B) MDSCs (CD33⁺CD11b⁺HLA-DR^−/low), (C) mMDSCs (CD33⁺CD11b⁺HLA-DR^−/lowCD14⁺), (D) gMDSCs (CD33⁺CD11b⁺HLA-DR^-/lowCD14⁻), (E) monocytes (CD33⁺CD11b⁺HLA-DR⁺CD14⁺), (F) dendritic cells (CD33⁺CD11b⁺HLA-DR⁺CD14⁻), (G) CD4⁺ T cells (CD3⁺CD4⁺CD8⁻) (H) Tregs (CD3⁺CD4⁺CD25⁺CD127⁻), and (I) CD8⁺ T cells (CD3⁺CD4⁻CD8⁺) in PBMCs of patients with CRLM (n = 41), HCC (n = 18), CCA (n = 18), NET (n = 5) and benign lesions (n = 18) and in healthy donors (n = 19) was analyzed with flow cytometry. *p < 0.05; **p < 0.01; ***p < 0.001 as determined for the myeloid and lymphoid populations by two-way ANOVA corrected for multiple comparisons with Tukey’s test. Only significant results are shown.