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. Author manuscript; available in PMC: 2021 Sep 1.
Published in final edited form as: Pain. 2020 Sep 1;161(9):2212–2224. doi: 10.1097/j.pain.0000000000001911

Figure 6. Itch-related neural classes target the meninges.

Figure 6.

(a) Selected images of fluorescent-WGA tracing from the meninges (green) superimposed on ISH signal for Nppb (red) confirm that C11 neurons innervate the meninges. (b) Selected images from WGA-tracing in Mrgpra3-Cre transgenic mice crossed into an Ai14 TdTomato Cre-dependent reporter background showing co-expression of Cre (blue, upper panels) and TdTomato (red) in neurons labeled by fluorescent WGA tracing from the meninges (green, lower panels). Data are from single sections through the trigeminal ganglion of 4 mice for (a) and 3 mice for (b); scale bar, 40 μm.