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. Author manuscript; available in PMC: 2021 Oct 1.
Published in final edited form as: Exp Hematol. 2020 Sep 15;90:65–71.e1. doi: 10.1016/j.exphem.2020.09.184

Figure 2.

Figure 2.

A 30-gene cluster can identify ALLs with B-1 and B-2 signatures. (A) Heatmap of supervised clustering of 127 pediatric ALLs (St. Jude Children’s Research Hospital, GSE26281) using 30 B-1 and B-2 progenitor genes. Columns represent individual samples, ranked by sample score from most B-1-like to most B-2-like, left to right. Rows represent each gene, ranked from most B-2-like to most B-1-like, top to bottom. The blue/red color scale indicates Z scores. (B) Sample scores for ALL subtypes (n≥10) in the St. Jude dataset that are more B-1-like (negative score) or more B-2-like (positive score). (C) Heatmap of supervised clustering of 107 pediatric ALLs (Dutch Childhood Oncology Group, GSE13351) using 30 B-1 and B-2 progenitor genes. Data presented as in Figure 2A. (D) Sample scores for ALL subtypes (n≥10) in the DCOG dataset. Data presented as in Figure 2B.