Table 1:
Time Post LT* (post-operative day (POD)) | Budesonide Group N=20 | Control Group N=20 |
---|---|---|
POD 0–3 | SISǂ + Intravenous corticosteroids | SISǂ + Intravenous corticosteroids |
POD 4–30 | SISǂ + Budesonide 9 mg | SISǂ + Prednisone 60 mg tapered to 15 mg |
POD 31–45 | SISǂ + Budesonide 6 mg | SISǂ + Prednisone 10 mg |
POD 46–90 | SISǂ + Budesonide 3 mg | SISǂ + Prednisone 10 mg tapered to discontinue |
POD ≥ 91 | SISǂ,¥ | SISǂ,¥ |
LT: Liver Transplant
SIS: standard immune suppression which consisted of the following: tacrolimus twice daily dosed to achieve goal trough level 8–12 ng/ml + mycophenolate mofetil 500 mg twice daily, +/− Thymoglobulin with goal CD3 suppression < 25 with delayed initiation of tacrolimus
If autoimmune hepatitis prior to LT continue prednisone 5 mg daily indefinitely