Table 5:

Summary of Liver allograft biopsies performed per study group

Study Group	Time post Liver Transplant that Liver Biopsy performed (post-operative day (POD))	Key Findings
Budesonide 3	POD 4	Patchy hepatocyte necrosis (25%) with sinusoidal hemorrhage suggestive of ischemic injury. Normal portal tracts
Budesonide 4	POD 5	Central venule and sinusoidal congestion suggestive of outflow obstruction
Budesonide 7*	POD 29	Acute cellular rejection with plasma rich infiltrates. Rejection activity index score was eight. A C4d stain was negative.
Budesonide 9	POD 74	Predominant lymphocytic portal inflammation aggregates suggestive of chronic viral hepatitis. Perivenular (zone 3) sinusoidal dilatation, congestion, hepatocellular dropout and fibrosis consistent with vascular outflow obstruction
Budesonide 10	POD 11	Patchy moderate cholestasis and mild bile ductular reactions (resolving ischemia-reperfusion injury). Mild regenerative hyperplasia-like changes and abnormal portal vein branches suggestive of vascular flow abnormality
Budesonide 11	POD 5	Mild ischemia reperfusion injury
Control 5ǂ	POD 8	Acute cellular rejection with a rejection activity index score of 5
Control 11	POD 5	Perivenular (zone 3) sinusoidal dilatation, congestion, hepatocellular dropout and fibrosis consistent with vascular outflow obstruction
Control 16	POD 4	Focal mild cholestasis and rare acidophil formation, favor ischemic/reperfusion injury

^*The patient in budesonide group that developed acute cellular rejection

^ǂThe patient in prednisone group that developed acute cellular rejection