Table 3.
Associations of baseline tubule function biomarkers with 50% eGFR decline or ESKD requiring dialysis or transplant among SPRINT participants with CKD (N = 2,428)
| Standard BP arm N = 30 events | Intensive BP arm N = 57 events | P-value for interaction | |
|---|---|---|---|
| Hazard Ratio (95% CI) | Hazard Ratio (95% CI) | ||
| Urine uromodulin (per 2-fold higher) | |||
| Model 1a | 0.56 (0.39, 1.79) | 0.74 (0.59, 0.94) | 0.039 |
| Model 2b | 0.79 (0.55, 1.15) | 0.88 (0.69, 1.12) | 0.035 |
| Model 3c | 0.69 (0.47, 1.02) | 0.83 (0.64, 1.09) | 0.032 |
| Urine β2m (per 2-fold higher) | |||
| Model 1a | 1.23 (1.03, 1.45) | 1.04 (0.94, 1.16) | 0.085 |
| Model 2b | 1.04 (0.88, 1.22) | 1.02 (0.92, 1.12) | 0.220 |
| Model 3c | 1.00 (0.85, 1.19) | 0.98 (0.89, 1.08) | 0.213 |
| Urine α1m (per 2-fold higher) | |||
| Model 1a | 2.40 (1.73, 3.33) | 1.38 (1.09, 1.74) | 0.010 |
| Model 2b | 1.48 (1.07, 2.03) | 1.14 (0.87, 1.50) | 0.011 |
| Model 3c | 1.29 (0.91, 1.82) | 0.94 (0.71, 1.26) | 0.008 |
Abbreviations: α1m, α1-microglobulin; β2m, β2-microglobulin; BP, blood pressure; CKD, chronic kidney disease; eGFR, estimated glomerular filtration rate; ESKD, end-stage kidney disease; HR, hazard ratio.
a
Adjusted for age, sex, race, and urine creatinine.
b
Adjusted for Model 1 covariates and baseline eGFR, smoking status, history of cardiovascular disease, baseline number of antihypertensive medications, systolic blood pressure, diastolic blood pressure, body mass index, high-density lipoprotein, and total cholesterol.
c
Adjusted for Model 2 covariates and urine albumin.