Probabilities of substance use endorsement by emergent classes. Five latent classes emerged: a class with a high probability of heavy alcohol and marijuana use (Heavy alcohol and marijuana), a class with high probabilities of all substances (High all polysubstance use), a class with high probabilities of illicit drugs (i.e., marijuana, cocaine, heroin, methamphetamine, ecstasy, and prescription drug misuse), a class with a high probability of marijuana use (primary marijuana), and a class with relatively low substance use probabilities (Low all).