Extended data figure:

Sequence alignment of ACE2 proteins from human, dog, macaca, masked palm civet, cat and mouse. Amino acid residues of human ACE2 that are experimentally shown to interact with the receptor binding domain (RBD) of SARS-CoV-2⁸ are denoted by *. Mutations known to disrupt the interaction between human ACE2 and RBD of SARS-CoV are highlighted in red boxes and these amino acid residues are all conserved between human and dog ACE2 proteins.