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. Author manuscript; available in PMC: 2021 Mar 7.
Published in final edited form as: Nat Neurosci. 2020 Sep 7;23(11):1399–1409. doi: 10.1038/s41593-020-0701-z

Fig. 5. Differential effects of extracellular dendritic and axonal stimulation.

Fig. 5

(a) Schematic showing whole-cell voltage clamp recording from a PC and extracellular current injection near the dendrite (40 μm from soma) or near the axon (30 μm from soma) used in (b) and (c). In (d) and (e) the somatic recording is an on-cell recording to monitor SSs.

(b) The waveform used for extracellular stimulation (Ex stim, top) and the resulting currents measured at the holding potential of −70 mV (blue) and −50 mV (red) by extracellular stimulation near the dendrites or near the axon.

(c) The relationship between the evoked currents and the intensity of extracellular stimulation near the dendrite (top) or axon (bottom) in voltage clamp at −70 mV (blue) and −50 mV (red).

(d) Experiments similar to (b) but examining the effect of extracellular stimulation on spontaneous SSs measured with on-cell recordings. Histograms of firing rate in response to extracellular stimulation near the dendrites or the axon.

(e) The relationship between firing rate and the intensity of extracellular stimulation near the dendrites (top) or the axon (bottom).

Data are mean ± s.e.m.