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. Author manuscript; available in PMC: 2021 Nov 1.
Published in final edited form as: Abdom Radiol (NY). 2020 Jul 31;45(11):3545–3556. doi: 10.1007/s00261-020-02677-2

Figure 4.

Figure 4.

Type I collagen–targeting macrocycle Gd-DOTA chelate based MRI probe, CM-101, for detection of liver fibrosis in mouse and rat models of liver fibrosis. (A) Representative T1-weighted images acquired pre CM-101 (baseline) and 10 min post CM-101 injection injection for vehicle- and CCl4-treated mice. (B) Representative T1-weighted images acquired pre CM-101 and 15 min post CM-101 injection in BDL rats and sham-operated rats. Note that the fibrotic liver is markedly enhanced with CM-101 but healthy liver is not.