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Summary of the top PC1 proteins with the greatest contribution to skin TEWL. (A) Top nine PC1 proteins identified by the classification model (LASSO generalized linear model, with 5-fold cross-validation) based on their contribution to skin TEWL. A univariate correlation analysis between SERPINB3 (B), GSN (C) and KRT77 (D) expression in skin tape strip samples and skin TEWL in the study cohort.
