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EL-CSG design and its efficacy in oral absorption enhancement. Glycocholic acid was conjugated to CS and then coated on Ex-4 loaded liposomes. After oral administration, EL-CSG was mainly absorbed by ASBT-mediated intestinal uptake in small intestine, with 19.5% oral bioavailability compared with s.c. injection. Reproduced, with permission, from reference [143].
