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(A–B) Tumor accumulation and antitumor activity of HDTA in KB tumor bearing mice. (C–D) Tumor accumulation and antitumor activity of HDTA4 and HTA3 in MDA-MB231 tumor bearing nude mice. (E) Tumor volume in in MDA-MB231 tumor bearing nude mice after HDTA4 and HTA3 treatment. (F) Schematic illustration of HDTA for oral delivery of DTX using bile acid transporter. Reproduced, with permission, from reference [152].
