NTCP |
Liver, basolateral |
Uptake of bile acids into hepatocytes |
Na+-dependent |
[67] |
OATP |
Liver, basolateral |
Uptake of bile acids into hepatocytes |
Na+-independent |
[102] |
FABP |
Liver, cytosolic |
Shuttle bile acids from basolateral to apical side |
For hydrophilic bile acids |
[68] |
MDR1/3/4 |
Liver, basolateral |
Efflux of bile acids back to blood |
Relieve liver load |
[72] |
BSEP |
Liver, apical |
Efflux of bile acids from hepatocytes |
High specificity |
[67, 71] |
MDR2 |
Liver, apical |
Efflux of bile acids from hepatocytes |
Divalent substrates |
[64] |
ASBT |
Ileum, apical |
Uptake of bile acids into enterocytes |
Na+-independent, |
[58] |
IBABP |
Ileum, cytosolic |
Shuttle bile acids from apical to basolateral side |
Unclear mechanism |
[94] |
OSTα/β |
Ileum, basolateral |
Efflux of bile acids from enterocytes |
Facilitated diffusion |
[100] |