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. Author manuscript; available in PMC: 2021 Nov 10.
Published in final edited form as: J Control Release. 2020 Jul 22;327:100–116. doi: 10.1016/j.jconrel.2020.07.034

Table 2.

Bile acid transporters

Name Distribution Function Note References
NTCP Liver, basolateral Uptake of bile acids into hepatocytes Na+-dependent [67]
OATP Liver, basolateral Uptake of bile acids into hepatocytes Na+-independent [102]
FABP Liver, cytosolic Shuttle bile acids from basolateral to apical side For hydrophilic bile acids [68]
MDR1/3/4 Liver, basolateral Efflux of bile acids back to blood Relieve liver load [72]
BSEP Liver, apical Efflux of bile acids from hepatocytes High specificity [67, 71]
MDR2 Liver, apical Efflux of bile acids from hepatocytes Divalent substrates [64]
ASBT Ileum, apical Uptake of bile acids into enterocytes Na+-independent, [58]
IBABP Ileum, cytosolic Shuttle bile acids from apical to basolateral side Unclear mechanism [94]
OSTα/β Ileum, basolateral Efflux of bile acids from enterocytes Facilitated diffusion [100]