Table 2.
Bile acid transporters
Name | Distribution | Function | Note | References |
---|---|---|---|---|
NTCP | Liver, basolateral | Uptake of bile acids into hepatocytes | Na+-dependent | [67] |
OATP | Liver, basolateral | Uptake of bile acids into hepatocytes | Na+-independent | [102] |
FABP | Liver, cytosolic | Shuttle bile acids from basolateral to apical side | For hydrophilic bile acids | [68] |
MDR1/3/4 | Liver, basolateral | Efflux of bile acids back to blood | Relieve liver load | [72] |
BSEP | Liver, apical | Efflux of bile acids from hepatocytes | High specificity | [67, 71] |
MDR2 | Liver, apical | Efflux of bile acids from hepatocytes | Divalent substrates | [64] |
ASBT | Ileum, apical | Uptake of bile acids into enterocytes | Na+-independent, | [58] |
IBABP | Ileum, cytosolic | Shuttle bile acids from apical to basolateral side | Unclear mechanism | [94] |
OSTα/β | Ileum, basolateral | Efflux of bile acids from enterocytes | Facilitated diffusion | [100] |