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AFM and TEM demonstrated uniform, spherical alginate nanoparticle structures with minimal to no aggregation. The picture shown in (A) is a representative tapping-mode AFM image of CCL21-containing alginate nanoparticles deposited from aqueous solution onto APS-mica. The panels shown in (B) and (C) display TEM-negative staining of the empty alginate nanoparticles and CCL21-loaded nanoparticles, respectively.
