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Pharmacokinetic parameters of CP-125.
| Compound | Route | Dose (mg/kg) | t1/2(h) | AUC0 – ∞(μM h) | F (%) |
|---|---|---|---|---|---|
| CP-125 (pure) | i.v. | 3 | 0.9 ± 0.1 | 4.1 ± 0.3 | 100 |
| p.o. | 15 | 1.4 ± 0.2 | 1.3 ± 0.4 | 6.3 | |
| CP-125 (from CO-125) | p.o. | 25 | 1.0 ± 0.1 | 1.1 ± 0.3 |
t1/2: terminal half-life; AUC0 – ∞: area under the plasma drug concentration curve from time zero to infinity; F: bioavailability. Results are presented as the mean ± SD (n ≥ 3).
