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Published in final edited form as: Trends Immunol. 2020 Oct 7;41(11):1023–1036. doi: 10.1016/j.it.2020.09.002

Table I. Mouse Strains Useful for the Study of Bhlhe40 and Bhlhe41^a.

Mouse strain	Notes	Ref.
Bhlhe40^−/−	Global deletion of Bhlhe40	[8,10,86]
Bhlhe41^−/−	Global deletion of Bhlhe41	[32,87]
Cd4-Cre⁺ Bhlhe40^fl/fl	Deletion of Bhlhe40 in T cells	[17,29,60]
LysM-Cre⁺ Bhlhe40^fl/fl	Deletion of Bhlhe40 in macrophages, monocytes, and neutrophils	[29, 51]
Cd11c-Cre⁺ Bhlhe40^fl/fl	Deletion of Bhlhe40 in DCs and alveolar macrophages	[29]
Mrp8-Cre⁺ Bhlhe40^fl/fl	Deletion of Bhlhe40 in neutrophils	[29]
Clast5-Tg	Overexpression of Bhlhe40 in B and T cells	[38]
Dec1-Tg	Overexpression of Bhlhe40 in T cells	[8]
Dec2-Tg	Overexpression of Bhlhe41 in T cells	[88]
Bhlhe40^GFP	Bhlhe40 BAC transgenic reporter strain	[13]
Bhlhe41-Cre-hCD2	cre-IRES-hCD2 gene expression under control of Bhlhe4l BAC	[39]
Bhlhe41^Tag	Bhlhe41 with multiple tag epitopes (FLAG and V5)	[39]
FLAG-Dec2	Bhlhe41 with FLAG tag expressed under hCD2 promoter control	[32]

^a

HHCD2 denotes human CD2.