Figure 1. STING^−/− mice develop more severe colitis upon enteric infection of Citrobacter rodentium.

WT mice (n = 4) and STING^−/− mice (n = 4) were given 200 μl PBS containing 5 × 10⁸ CFU of Citrobacter rodentium by oral gavage. (A) weight changes were monitored daily. (B) Histological scores. (C) Representative histopathology of the colons from WT and STING^−/− mice 10 days post-infection. Scale bar, 300μm. (D) Fecal colony-forming units (CFU) were quantified on day 7. *p < 0.05. Data were represented as means ± standard deviation. One representative of 3 experiments with similar results was shown.