TABLE 4.

Genome wide association studies in NSCPO cohorts.

SNP information	Locus	Gene#	Country	Sample size	P-value†	OR (95% CI)	References
			49% Europe – 47% Asia – 3% Africa	550 triads	NS		Beaty et al. (2011), Shi et al. (2012), and Ludwig et al. (2017)
rs41268753	1p36.11	GRHL3	Europe	38 cases – 93 – triads – 835 controls	4.08 × 10–9	8.3 (1.17–59.15)	Leslie et al. (2016)
rs117496742	11q22.1	YAP1	Europe	38 cases – 93 – triads – 835 controls	3.13 × 10–8	11.2 (1.04–121.8)	Leslie et al. (2016)
rs12175475	6p26	PARK2	Multiethnic	78 cases – 165 triads – 1700 controls	8.66 × 10–9	6.6 (1.12–39.58)	Leslie et al. (2016)
rs80004662	2p12	CTNNA2	Sub-Saharan Africa	205 cases – 2159 controls	7.41 × 10–9	7.5 (3.45–16.28)	Butali et al. (2019)
rs730570	14q32.2	DLK1	China	2071 cases – 10145 controls	6.59 × 10–10	1.28	Huang et al. (2019)
rs4646211	13q32.3	DOCK9	China	2071 cases – 10145 controls	4.78 × 10–12	1.28	Huang et al. (2019)
rs8061677	16q24.2	FOXC2-FOXL1	China	2071 cases – 10145 controls	9.11 × 10–11	1.29	Huang et al. (2019)
rs72741048	1q32.2	IRF6	China	2071 cases – 10145 controls	3.07 × 10–15	1.314	Huang et al. (2019)
rs1009136	19p13.11	MAU2	China	2071 cases – 10145 controls	2.66 × 10–9	1.25	Huang et al. (2019)
rs730643	14q13.3	PAX9	China	2071 cases – 10145 controls	2.92 × 10–16	0.74	Huang et al. (2019)
rs6791526	3p22.1	POMGNT2	China	2071 cases – 10145 controls	1.62 × 10–10	1.46	Huang et al. (2019)
rs3468	4p16.3	WHSC1	China	2071 cases – 10145 controls	5.4 × 10–11	1.256	Huang et al. (2019)

^#Further information about the molecular function, biological process and relative pathway is given in Supplementary Table S4. ^†NS, not significant SNP detected.