Table 1. Top 20 differentially expressed genes from each sample from periodontitis patients compared to healthy patients.
| Gene symbol | Definition | Fold change | P value | |
|---|---|---|---|---|
| Upregulated genes: gingival tissue | ||||
| CD79A | CD79a molecule, immunoglobulin-associated alpha | 10.70 | 4.38E-06 | |
| IGLL3 | Immunoglobulin lambda-like polypeptide 3 | 9.83 | 3.49E-05 | |
| JSRP1 | Junctional sarcoplasmic reticulum protein 1 | 9.05 | 4.86E-05 | |
| LOC649923 | Similar to Ig gamma-2 chain C region | 9.01 | 9.24E-04 | |
| CAMK1G | Calcium/calmodulin-dependent protein kinase IG | 8.99 | 4.01E-06 | |
| MMP7 | Matrix metallopeptidase 7 | 8.76 | 3.50E-05 | |
| LOC652694 | Similar to Ig kappa chain V-I region HK102 | 8.46 | 9.60E-05 | |
| FAM46C | Family with sequence similarity 46,member C | 7.70 | 7.30E-06 | |
| MGC29506 | Hypothetical protein MGC29506 (MGC29506) | 7.59 | 8.92E-05 | |
| LOC652102 | Ig heavy chain V-I region HG3 precursor | 7.53 | 3.16E-04 | |
| LOC647506 | Hypothetical LOC647506 | 7.44 | 4.67E-04 | |
| MMP7 | Matrix metallopeptidase 7 | 7.28 | 2.82E-05 | |
| LOC651751 | Similar to Ig kappa chain V-II region RPMI 6410 p | 7.07 | 1.10E-03 | |
| LOC647450 | Similar to Ig kappa chain V-I region HK101 | 6.98 | 1.21E-03 | |
| TNFRSF17 | Tumor necrosis factor receptor superfamily, member 17 | 6.81 | 1.75E-06 | |
| LOC652493 | Similar to Ig kappa chain V-I region HK102 | 6.45 | 1.69E-03 | |
| CRKRS | Cdc2-related kinase, arginine/serine-rich | 6.29 | 1.45E-06 | |
| RGS1 | Regulator of G-protein signaling 1 | 6.11 | 7.35E-06 | |
| RNF126P1 | Ring finger protein 126 pseudogene 1 | 6.11 | 1.29E-05 | |
| LOC642113 | Similar to Ig kappa chain V-III region HAH precursor | 5.93 | 2.92E-03 | |
| Downregulated genes: gingival tissue | ||||
| LOR | Loricrin | −22.22 | 6.52E-05 | |
| KRT1 | Keratin 1 | −20.30 | 3.89E-05 | |
| C6orf15 | Chromosome 6 open reading frame 15 | −13.06 | 4.69E-06 | |
| KRT2 | Keratin 2 | −12.62 | 5.18E-05 | |
| ASPRV1 | Aspartic peptidase, retroviral-like 1 | −11.42 | 7.54E-06 | |
| LCE2B | Late cornified envelope 2B | −10.52 | 2.20E-05 | |
| CDSN | Corneodesmosin | −9.91 | 7.31E-06 | |
| RPTN | Repetin (RPTN) | −9.89 | 1.26E-04 | |
| LCE2D | Late cornified envelope 2D | −9.45 | 1.16E-05 | |
| KRT76 | Keratin 76 | −9.25 | 1.07E-04 | |
| KPRP | Keratinocyte proline-rich protein | −8.83 | 3.07E-06 | |
| LCE2A | Late cornified envelope 2A | −8.65 | 6.05E-05 | |
| LCE2C | Late cornified envelope 2C | −8.54 | 1.15E-05 | |
| LCE3A | Late cornified envelope 3A | −8.19 | 6.30E-05 | |
| KRT3 | Keratin 3 (KRT3) | −7.29 | 1.31E-04 | |
| FLG | Filaggrin (FLG) | −6.58 | 3.58E-04 | |
| LCE3D | Late cornified envelope 3D | −6.56 | 3.34E-05 | |
| LY6G6C | Lymphocyte antigen 6 complex, locus G6C | −6.47 | 6.12E-07 | |
| LCE3E | Late cornified envelope 3E | −6.44 | 4.89E-06 | |
| SLURP1 | Secreted LY6/PLAUR domain containing 1 | −5.70 | 6.30E-07 | |
| Up-regulated genes: saliva | ||||
| VPS41 | Vacuolar protein sorting 41 homolog | 3.18 | 6.00E-03 | |
| ZNF786 | Zinc finger protein 786 | 2.81 | 2.61E-02 | |
| LOC389765 | Similar to KIF27C | 2.79 | 1.23E-02 | |
| ZNF738 | Misc_RNA | 2.65 | 1.40E-02 | |
| LOC100132585 | Hypothetical protein LOC100132585 | 2.59 | 1.58E-02 | |
| LOC100129502 | Hypothetical protein LOC100129502 | 2.57 | 1.09E-02 | |
| PNPT1 | Polyribonucleotide nucleotidyltransferase 1 | 2.54 | 1.02E-02 | |
| C15orf63 | Chromosome 15 open reading frame 63 | 2.49 | 2.83E-02 | |
| LOC100131718 | Misc_RNA | 2.48 | 3.52E-02 | |
| NLRP8 | NLR family, pyrin domain containing 8 | 2.46 | 2.04E-02 | |
| FLJ36131 | Hypothetical protein FLJ36131 | 2.41 | 2.22E-02 | |
| ZNF223 | Zinc finger protein 223 | 2.40 | 1.75E-02 | |
| SLC35E1 | Solute carrier family 35, member E1 | 2.39 | 3.21E-02 | |
| C5orf28 | Chromosome 5 open reading frame 28 | 2.36 | 1.69E-02 | |
| LOC644250 | Hypothetical protein LOC644250 | 2.33 | 1.75E-02 | |
| CCDC125 | Coiled-coil domain containing 125 | 2.33 | 9.45E-03 | |
| DUXAP3 | Double homeobox A pseudogene 3 | 2.33 | 4.95E-02 | |
| FAM73A | Family with sequence similarity 73, member A | 2.32 | 2.74E-02 | |
| FLJ40722 | Hypothetical protein FLJ40722 | 2.30 | 1.83E-02 | |
| N4BP2 | Nedd4 binding protein 2 | 2.25 | 1.08E-02 | |
| Down-regulated genes: saliva | ||||
| SPRR3 | Small proline-rich protein 3 | −15.26 | 3.10E-03 | |
| IL1B | Interleukin 1, beta | −14.12 | 1.33E-02 | |
| FTHL7 | Ferritin, heavy polypeptide-like 7 | −12.53 | 8.73E-03 | |
| FTHL16 | Misc_RNA | −10.08 | 7.71E-03 | |
| SPRR2D | Small proline-rich protein 2D | −9.91 | 4.98E-03 | |
| ACTB | Actin, beta | −9.89 | 3.44E-03 | |
| SPRR2A | Small proline-rich protein 2A | −9.67 | 5.49E-03 | |
| KRT13 | Keratin 13 | −9.55 | 4.85E-03 | |
| S100A9 | S100 calcium binding protein A9 | −8.39 | 1.01E-02 | |
| IL8 | Interleukin 8 | −8.19 | 2.95E-02 | |
| CRNN | Cornulin | −7.40 | 3.32E-03 | |
| ZFP36 | Zinc finger protein 36, C3H type | −6.46 | 1.67E-02 | |
| TPT1 | Tumor protein, translationally-controlled 1 | −6.45 | 1.67E-02 | |
| SPRR2F | Small proline-rich protein 2F | −6.21 | 1.70E-02 | |
| KRT6A | Keratin 6A | −6.03 | 1.72E-02 | |
| IL1RN | Interleukin 1 receptor antagonist | −5.89 | 4.54E-03 | |
| S100A8 | S100 calcium binding protein A8 | −5.72 | 2.97E-02 | |
| B2M | Beta-2-microglobulin | −5.64 | 1.74E-02 | |
| ACTG1 | Actin, gamma 1 | −5.59 | 2.57E-02 | |
| PLEK | Pleckstrin | −5.37 | 3.08E-02 | |
Upregulated genes in gingival tissue samples; downregulated genes in gingival tissue samples; upregulated genes in saliva samples; downregulated genes in saliva samples. Genes involved in overlapped enriched pathways between the results from the gingival tissue and saliva samples are gray-shaded.