Table 5. Pathway analysis with ConsensusPathDB (adjusted P<0.02).
Pathway | Source | Percentage | P value | Adj. P (FDR) |
---|---|---|---|---|
Direct p53 effectors | PID | 6 (4.2%) | <0.001 | <0.001 |
E2F transcription factor network | PID | 4 (5.3%) | <0.001 | 0.002 |
Regulation of TP53 expression and degradation | Wikipathways | 2 (50.0%) | <0.001 | 0.002 |
FOXM1 transcription factor network | PID | 3 (7.1%) | <0.001 | 0.006 |
HATs acetylate histones | Reactome | 4 (2.8%) | <0.001 | 0.014 |
Integrated breast cancer pathway | Wikipathways | 3 (4.5%) | <0.001 | 0.016 |
Polo-like kinase mediated events | Reactome | 2 (12.5%) | <0.001 | 0.016 |
Herpes simplex infection - Homo sapiens (human) | KEGG | 4 (2.2%) | 0.001 | 0.018 |
Cellular senescence | Reactome | 4 (2.1%) | 0.001 | 0.018 |
C-MYB transcription factor network | PID | 3 (3.5%) | 0.001 | 0.018 |
miRNA regulation of DNA damage response | Wikipathways | 3 (3.4%) | 0.001 | 0.018 |
Cellular responses to stress | Reactome | 5 (1.5%) | 0.002 | 0.018 |
B-WICH complex positively regulates rRNA expression | Reactome | 3 (3.2%) | 0.002 | 0.018 |
Formation of the beta-catenin: TCF transactivating complex | Reactome | 3 (3.2%) | 0.002 | 0.018 |
FDR: false discovery rate, PID: Pathway Interaction Database, KEGG: Kyoto Encyclopedia of Genes and Genomes.