TABLE 1.

Different schemas of resistance to immunotherapy.

Schemas	Classifications	Description
Temporal perspective	Primary	Lack of initial response or clinical benefit to therapy
	Acquired	Disease progression after an initial period (6 months) of clinical benefit
Spatial perspective	Intrinsic	Tumor-related resistance
	Extrinsic	Factors involved in microenvironment or tumor-immunity cycle
Immunological perspective	Immune inflamed	Tumor inhibits immune activities notwithstanding abundant immune cells infiltration
	Immune desert	Tumor fails to evoke an immunoreaction
	Immune excluded	Tumor prevents immune cells infiltration in spite of adequate immunogenicity