Table 1.

Clinical features of younger patients with mantle cell lymphoma in the indicated eras.

	Era
Clinical features	1995–2000	2001–2012	2013–2016	Total	P*
	(N = 571)	(n = 3,073)	(n = 1,248)	(n = 4,892)
Age N(%)					<0.001
<50	146 (25.6%)	501 (16.3%)	158 (12.7%)	805 (16.5%)
50–59	234 (41.0%)	1,361 (44.3%)	530 (42.5%)	2,125 (43.4%)
60-65	191 (33.5%)	1,211 (39.4%)	560 (44.9%)	1,962 (40.1%)
Sex N(%)					0.526
Female	160 (28.0%)	793 (25.8%)	322 (25.8%)	1,275 (26.1%)
Male	411 (72.0%)	2,280 (74.2%)	926 (74.2%)	3,617 (73.9%)
Stage N(%)					<0.001
Early	130 (22.8%)	433 (14.1%)	103 (8.3%)	666 (13.6%)
Advanced	400 (70.1%)	2,459 (80.0%)	818 (65.5%)	3,677 (75.2%)
Unknown	41 (7.2%)	181 (5.9%)	327 (26.2%)	549 (11.2%)
Race N(%)					0.008
Non-hispanic white	462 (80.9%)	2426 (78.9%)	953 (76.4%)	3,841 (78.5%)
Non-hispanic black	39 (6.8%)	174 (5.7%)	71 (5.7%)	284 (5.8%)
Hispanic	37 (6.5%)	324 (10.5%)	158 (12.7%)	519 (10.6%)
Other	33 (5.8)	149 (4.8%)	66 (5.3%)	248 (5.1%)

^*Chi-square test was performed to compare the clinical features over time.