Table 3.

Univariate and multivariate analysis of clinical parameters associated with overall survival in younger patients with MCL.

Variable	Univariate analysis		Multivariate analysis
	Hazard ratio(95% CI)	P	Hazard ratio(95% CI)	P
Year of diagnosis
1995–2000	Reference	-	Reference	-
2001–2012	0.646 (0.570–0.731)	<0.001	0.589 (0.519–0.667)	<0.001
2013–2016	0.513 (0.419–0.629)	<0.001	0.459 (0.374–0.564)	<0.001
Age, years
<50	Reference	-	Reference	-
50–59	1.171 (1.009–1.359)	0.038	1.240 (1.067–1.441)	0.005
60–65	1.240 (1.066–1.442)	0.005	1.332 (1.144–1.550)	<0.001
Race
Non-hispanic black	Reference	-	Reference	-
Hispanic	1.166 (0.899–1.512)	0.248	1.173 (0.901–1.528)	0.235
Non-hispanic white	0.954 (0.767-1.185)	0.668	0.924 (0.741-1.151)	0.479
Other	0.871 (0.629-1.206)	0.405	0.865 (0.624-1.197)	0.381
Stage
Early stage	Reference	-	Reference	-
Advanced stage	1.628 (1.384–1.915)	<0.001	1.739 (1.479–2.045)	<0.001
Other	1.100 (0.845–1.432)	0.479	1.157 (0.887–1.508)	0.282
Sex
Female	Reference	-	Reference	-
Male	1.280 (1.130–1.449)	<0.001	1.279 (1.129–1.448)	<0.001