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. 2020 Oct 20;8:585619. doi: 10.3389/fcell.2020.585619

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Copyright © 2020 Ji, Zhu, Wang and Huang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The mechanism of cortactin-induced cytoskeletal remodeling during the epithelial–mesenchymal transition (EMT). Remodeling of the cytoskeleton requires the coordination of several processes, including the protrusion of a lamellipodium at the leading edge, adhesion, contraction of the actin bundle, and retraction of the trailing edge of the cell. Cortactin regulates cytoskeletal remodeling by interacting with Arp2/3, neural Wiskott–Aldrich syndrome protein (N-WASP), and other proteins. Then, it promotes the EMT.