Table 3.
Univariate and multivariate analysis of CSS in the training set (n=1,644).
| Characteristics | No. of patient | Univariate analysis | Multivariate analysis | ||
|---|---|---|---|---|---|
| HR(95%CI) | P value | HR(95%CI) | P value | ||
| Gender | |||||
| Male | 821 | Reference | Reference | ||
| Female | 823 | 0.9(0.8–1) | 0.044 | 0.88(0.79–0.98) | 0.019 |
| Age | |||||
| ≤37 | 296 | Reference | Reference | ||
| 38–47 | 988 | 0.9(0.78–1.04) | 0.156 | 0.9(0.78–1.04) | 0.169 |
| ≥48 | 360 | 0.93(0.78–1.1) | 0.407 | 0.95(0.8–1.12) | 0.523 |
| Race | |||||
| White | 1126 | Reference | – | – | |
| Black | 304 | 0.98(0.85–1.13) | 0.762 | – | – |
| Other* | 214 | 0.96(0.82–1.13) | 0.614 | – | – |
| Grade | |||||
| Well | 104 | Reference | – | – | |
| Moderately | 1245 | 0.98(0.79–1.21) | 0.833 | – | – |
| Poorly | 249 | 0.87(0.68–1.12) | 0.279 | – | – |
| Undifferentiated | 46 | 1.07(0.71–1.62) | 0.745 | – | – |
| Tumor size | |||||
| ≤2.4cm | 199 | Reference | Reference | ||
| 2.5–4.7cm | 642 | 1.24(1.04–1.47) | 0.014 | 1.4(1.13–1.74) | 0.002 |
| ≤4.7cm | 803 | 1.11(0.94–1.31) | 0.213 | 1.28(1.02–1.6) | 0.034 |
| AJCC T stage (7th) | |||||
| T1 | 147 | Reference | Reference | ||
| T2 | 187 | 0.95(0.76–1.18) | 0.625 | 0.8(0.62–1.02) | 0.077 |
| T3 | 981 | 0.98(0.82–1.17) | 0.821 | 0.76(0.6–0.97) | 0.028 |
| T4a | 224 | 1.02(0.8–1.28) | 0.901 | 0.76(0.57–1.02) | 0.064 |
| T4b | 105 | 1.26(0.94–1.7) | 0.129 | 0.98(0.69–1.38) | 0.9 |
| AJCC N stage (7th) | |||||
| N0 | 751 | Reference | – | – | |
| N1 | 527 | 1(0.89–1.13) | 0.966 | – | – |
| N2 | 366 | 1.07(0.92–1.25) | 0.359 | – | – |
| AJCC M stage (7th) | |||||
| M0 | 1374 | Reference | Reference | ||
| M1 | 270 | 1.14(0.94–1.4) | 0.191 | 0.91(0.73–1.14) | 0.399 |
| Regional nodes | |||||
| Positive | 858 | Reference | Reference | ||
| Negative | 786 | 0.45(0.27–0.75) | 0.002 | 0.45(0.27–0.75) | 0.002 |
| Tumor deposits | |||||
| Positive | 192 | Reference | Reference | ||
| Negative | 1452 | 0.64(0.53–0.77) | <0.001 | 0.66(0.54–0.8) | <0.001 |
| Bone metastasis | |||||
| Yes | 2 | Reference | – | – | |
| No | 1642 | 59963.62(0–Inf) | 0.985 | – | – |
| Liver metastasis | |||||
| Yes | 197 | Reference | – | – | |
| No | 1447 | 0.95(0.75–1.2) | 0.659 | – | – |
| Lung metastasis | |||||
| Yes | 40 | Reference | Reference | ||
| No | 1604 | 0.39(0.23–0.67) | 0.001 | 0.45(0.26–0.8) | 0.006 |
| Perineural invasion | |||||
| Yes | 248 | Reference | Reference | ||
| No | 1396 | 0.79(0.66–0.93) | 0.005 | 0.82(0.69–0.99) | 0.035 |
*Two-sided P values <0.05; HR, hazard ratio; CI, confidence intervals; AJCC, American Joint Committee on Cancer; TNM, tumor-node-metastasis.