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. 2020 Oct;8(19):1223. doi: 10.21037/atm-20-2444

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2020 Annals of Translational Medicine. All rights reserved.

Open Access Statement: This is an Open Access article distributed in accordance with the Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License (CC BY-NC-ND 4.0), which permits the non-commercial replication and distribution of the article with the strict proviso that no changes or edits are made and the original work is properly cited (including links to both the formal publication through the relevant DOI and the license). See: https://creativecommons.org/licenses/by-nc-nd/4.0.

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Enrollment flowchart. After inclusion and exclusion, 8,310 compensated liver cirrhotic patients with low-risk EV enrolled in our study from January 2001 to February 2018. After excluding patients who had undergone prophylactic therapy with EVL, the remaining 6,803 patients without NSBB prophylaxis were the main group for primary endpoint analysis. The minor group was 281 matched patients (3.97%) with NSBB prophylaxis for secondary endpoint analysis. EV, esophageal variceal; EVL, endoscopic variceal ligation; NSBB, non-selective beta-blockers.