Table 3. Incidence rate per 1,000 person-years and radioactive iodine dose-dependent hazard ratio of specific cardiovascular diseases in patients with thyroid cancer who received RAI treatment compared to those who did not.
| Outcomes | Events (n) | Incidence rate (per 1,000 person-years) | Unadjusted | Adjusted* | |||
|---|---|---|---|---|---|---|---|
| HR (95% CI) | P value | HR (95% CI) | P value | ||||
| Cardiovascular disease | |||||||
| No RAI (n=2,312) | 199 (8.6) | 17.32 (15.07–19.90) | 1 (reference) | 1 (reference) | |||
| Cumulative RAI dose <100 mCi (n=1,045) | 91 (8.7) | 14.71 (11.98–18.07) | 0.90 (0.70–1.15) | 0.407 | 0.91 (0.70–1.18) | 0.452 | |
| Cumulative RAI dose ≥100 mCi (n=1,488) | 113 (7.6) | 13.41 (11.15–16.12) | 0.81 (0.64–1.02) | 0.074 | 0.85 (0.67–1.08) | 0.173 | |
| IS | |||||||
| No RAI | 38 (1.6) | 3.12 (2.27–4.29) | 1 (reference) | 1 (reference) | |||
| Cumulative RAI dose <100 mCi | 17 (1.6) | 2.6 (1.62–4.18) | 0.87 (0.49–1.54) | 0.622 | 0.92 (0.51–1.69) | 0.798 | |
| Cumulative RAI dose ≥100 mCi | 19 (1.3) | 2.14 (1.37–3.36) | 0.70 (0.41–1.22) | 0.211 | 0.77 (0.44–1.35) | 0.357 | |
| IHD | |||||||
| No RAI | 154 (6.67) | 13.21 (11.28–15.47) | 1 (reference) | 1 (reference) | |||
| Cumulative RAI dose <100 mCi | 67 (6.4) | 10.67 (8.4–13.56) | 0.86 (0.64–1.14) | 0.292 | 0.86 (0.64–1.16) | 0.329 | |
| Cumulative RAI dose≥100 mCi | 95 (6.4) | 11.17 (9.14–13.66) | 0.89 (0.69–1.14) | 0.351 | 0.93 (0.71–1.20) | 0.560 | |
| HS | |||||||
| No RAI | 14 (0.6) | 1.14 (0.68–1.93) | 1 (reference) | 1 (reference) | |||
| Cumulative RAI dose <100 mCi | 13 (1.2) | 1.98 (1.15–3.41) | 1.74 (0.82–3.70) | 0.152 | 1.67 (0.76–3.68) | 0.203 | |
| Cumulative RAI dose ≥100 mCi | 5 (0.3) | 0.56 (0.23–1.34) | 0.49 (0.18–1.36) | 0.172 | 0.52 (0.18–1.45) | 0.210 | |
| Cerebrovascular disease | |||||||
| No RAI | 97 (4.2) | 8.08 (6.62–9.86) | 1 (reference) | 1 (reference) | |||
| Cumulative RAI dose <100 mCi | 53 (5.1) | 8.26 (6.31–10.82) | 1.06 (0.76–1.48) | 0.744 | 1.05 (0.74–1.50) | 0.778 | |
| Cumulative RAI dose ≥100 mCi | 50 (3.4) | 5.7 (4.32–7.52) | 0.72 (0.51–1.02) | 0.063 | 0.76 (0.53–1.07) | 0.116 | |
| HF | |||||||
| No RAI | 22 (1.0) | 1.8 (1.18–2.73) | 1 (reference) | 1 (reference) | |||
| Cumulative RAI dose <100 mCi | 12 (1.2) | 1.83 (1.04–3.22) | 1.06 (0.52–2.14) | 0.871 | 0.97 (0.46–2.04) | 0.935 | |
| Cumulative RAI dose ≥100 mCi | 13 (0.9) | 1.46 (0.85–2.52) | 0.84 (0.42–1.66) | 0.613 | 0.84 (0.42–1.69) | 0.624 | |
*, adjusted for age, sex, body mass index, socioeconomical status, smoking, alcohol consumption, levothyroxine dosage, and previous history of hypertension, diabetes mellitus, dyslipidemia, and cardiovascular disease. RAI, radioactive iodine; IS, ischemic stroke; IHD, ischemic heart disease; HS, hemorrhagic stroke; HF, heart failure; CI, confidence interval.