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. 2020 Jul 1;14(11):2814–2833. doi: 10.1002/1878-0261.12747

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© 2020 The Authors. Published by FEBS Press and John Wiley & Sons Ltd.

This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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Fig. 6 — Immune‐related profiling, tumor‐infiltrating immune cells, and genomic heterogeneity in the CIHI‐based groups. (A) Box and whisker plots show the expression of selected immune‐related genes in the METABRIC cohort. (B, C) TMB and the MATH score in the high‐CIHI and low‐CIHI groups. (D) Comparison of infiltrating immune cells (CIBERSORT) between groups. The hypoxia^high/immune^low and hypoxia^low/immune^high phenotypes are represented as dark red and dark blue, respectively. Student’s t‐test and Wilcox test were used for data analysis. P values are shown as **P < 0.01 and ***P < 0.001.