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. 2020 Sep 1;14(11):2853–2867. doi: 10.1002/1878-0261.12780

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© 2020 The Authors. Published by FEBS Press and John Wiley & Sons Ltd.

This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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Fig. 3 — Association of gluconeogenic enzyme expression in lung adenocarcinoma with overall survival. (A) Kaplan–Meier survival functions +/‐ 95% confidence interval in LUAD patients with positive or negative PCK1, PCK2, LDHB and GLUT1 staining (cutoff = 1). (B) Kaplan–Meier estimators of the publicly available TCGA LUAD data for PCK2 and GLUT1 (SLC2A1) mRNA, respectively (n = 491; data were retrieved via the UCSC Xena platform, https://xenabrowser.net/). Median values were used as the cutoff. (C) Overall survival in LUAD patients according to the metabolic phenotype. (A–C) Differences in survival were calculated using the Logrank test.