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. 2020 Nov 3;473(2):139–150. doi: 10.1007/s00424-020-02482-2

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© The Author(s) 2020

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Fig. 3 — (A) RBCs are located in the middle of the bloodstream, surrounded by a cell-free plasma layer. At bifurcations, the RBC concentration decreases (plasma skimming) [79]. (B) The nano-sized PFC droplets (light grey) are equally distributed in the vessel and do not rely on plasma skimming [39]. (C) The uptake of O₂ into the PFC droplet happens fast, which shortens the diffusion distance between RBCs and endothelium whilst PFC droplets act as stepping-stones for O₂ [20]. Figure created with Biorender.com