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(A) Inhibitors of DosR. Compound 10 and HC104A inhibit DosR binding of promoter DNA. (B) Inhibitors of DosS and DosT. Artemisinin and HC106A inhibit DosS and DosT by interacting with the embedded heme sensor. HC102A and HC103A do not inhibit heme redox, but instead inhibit sensor kinase autophosphorylation.
