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. 2020 Oct;159(4):1328–1341.e3. doi: 10.1053/j.gastro.2020.06.012

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© 2020 The Authors

This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).

PMC Copyright notice

Mtg8 and Mtg16 deletion impairs intestinal lineage specification. Intestinal tissues were collected from newborn (P0) (n = 4–5 for each genotype) (A) Heatmap showing genes differentially expressed in WT and Mtg16−/− intestine. (B, D, E) Gene Set Enrichment Analysis (GSEA) probing (B) Wnt/Stem cell signature genes, (D) intestinal absorption and digestion, and (E) secretory signature genes. (C) FAPB1 and APOA4 immunostaining in adult WT and Mtg16−/− intestinal tissue. (F) Scheme showing the disaccharidase assay performed in organoids. (G) qRT-PCR of mature enterocyte markers in adult WT and Mtg16−/− organoids. (H) Glucose levels detected in the supernatant of intestinal organoids of the indicated genotypes after 1-hour sucrose incubation. ∗P < .05, ∗∗P < .01, ∗∗∗P < .001, 2-sided t-test.