Figure 5. . The molecular binding modes of 7e (yellow), 7b (orange) and SAHA (green) in the active site of HDAC2.

The subsets are (A) comparison of the binding of 7e and SAHA and (B) comparison of the binding of 7e and 7b. Important amino acids in the binding pocket that interact with the compound and/or chelate with the Zn²⁺ are shown in stick model with carbon in cyan.