Table 1. . Summary of validation outcomes: intra and inter day accuracies and precisions for vancomycin in human whole blood volumetric absorptive microsampling.
Conc. | Mean ± SD (μg/ml) | CV (%) | Accuracy (%) | Mean ± SD (μg/ml) | CV (%) | Accuracy (%) |
---|---|---|---|---|---|---|
Day 1 (n = 6 replicates) | Day 2 (n = 6 replicates) | |||||
1.00 | 1.12 ± 0.129 | 11.5 | 112 | 0.959 ± 0.114 | 11.9 | 95.9 |
2.50 | 2.68 ± 0.288 | 9.91 | 107 | 2.48 ± 0.085 | 3.45 | 99.1 |
40.0 | 39.8 ± 0.955 | 2.40 | 100 | 38.4 ± 1.73 | 4.50 | 96.1 |
80.0 | 84.3 ± 10.0 | 11.9 | 105 | 88.5 ± 9.80 | 11.1 | 111 |
Day 3 (n = 6 replicates) | Inter day (3 days, n = 18 replicates) | |||||
1.00 | 0.903 ± 0.082 | 9.09 | 90.3 | 0.993 ± 0.139 | 14.0 | 99.3 |
2.50 | 2.59 ± 0.253 | 9.74 | 104 | 2.59 ± 0.225 | 8.67 | 104 |
40.0 | 37.6 ± 1.57 | 4.16 | 94.0 | 38.6 ± 1.65 | 4.28 | 96.5 |
80.0 | 76.4 ± 3.76 | 4.92 | 95.4 | 83.0 ± 9.42 | 11.3 | 104 |