Table 5. . Vancomycin concentrations measured in whole blood volumetric absorptive microsampling and plasma with estimated plasma concentrations from volumetric absorptive microsampling in pediatric subjects.
| Subject | Dose (mg/kg/dose) | Bodyweight (kg) | Sampling time† (minutes) | Sample collection | HCT (%) | Vancomycin concentration (μg/ml) | ||
|---|---|---|---|---|---|---|---|---|
| Measured whole blood VAMS | Estimated in plasma from VAMS | Measured in plasma | ||||||
| 1 | 15 | 8.8 | 44 | Venous | 24.0 | 21.4 | 29.8 | 29.9 |
| 42 | Capillary | ND | 22.5 | 31.3 | ND | |||
| 2 | 10 | 12 | 199 | Venous | 25.9 | 7.18 | 10.0 | 6.9 |
| 201 | Capillary | ND | 7.66 | 10.7 | ND | |||
| 3 | 20 | 40 | 54 | Arterial | 33.1 | 17.0 | 23.7 | 21.9 |
| 54 | Capillary | ND | 18.9 | 26.3 | ND | |||
†
After end of infusion.
HCT: Hematocrit; VAMS: Volumetric absorptive microsampling.